New research reported at the Alzheimer’s Association International Conference (AAIC) 2019 in Los Angeles suggests that healthy lifestyle choices, especially physical activity, may decrease the risk of cognitive decline and dementia. David Llewellyn, researcher of the University of Exeter said that healthy lifestyle appears to be “the only tool to wind back the risk of dementia conferred by a bad deal from the genetic lottery”.
The study included 196 383 participants of European ancestry aged at least 60 years without dementia at baseline, participants with a high genetic risk and unfavourable lifestyle score had a statistically significant hazard ratio for incident all-cause dementia of 2.83 compared with participants with a low genetic risk and favourable lifestyle score.
A favourable lifestyle was associated with a lower risk of dementia and there was no significant interaction between genetic risk and healthy lifestyle. A healthy lifestyle was associated with lower risk of dementia among participants with low or high genetic risk.
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